Vkruk fought alongside Shinzon during the Dominion War, including the mission to Goloroth.
In 2379, Shinzon had risen to become Praetor of the Romulan Star Empire, and Vkruk served as his Viceroy and second-in-command of the Empire. He also stood at Shinzon's side when they attempted to take the Scimitar into Federation space and attack Earth with a Thalaron weapon. Vkruk relayed orders to the crew, monitored Shinzon's deterioating health, and assisted Shinzon in the telepathic rape of Deanna Troi.
In the final showdown with the USS Enterprise (NCC-1701-E), Vkruk led a boarding party aboard the Enterprise in order to find Captain Jean-Luc Picard and bring him to Shinzon so that a blood transfusion could save his life. Unfortunately, he was prevented from doing this by Commander William T. Riker, and later died in battle with Riker.