T'Prel was a Vulcan serving in Starfleet and assigned to the USS New York. In 2311, T'Prel went on a classified covert mission to Devron II with Demora Sulu and Michael Paris.
By the late 24th century, T'Prel had been transferred to the USS Aventine and served as a security crewman. In 2381, T'Prel was one of the security personnel under away team security supervisor Naomi Darrow who discovered the bodies of Yott and Komer; the four were sworn to keep the deaths secret until they had more information.
The Aventine was one of the vessels launching a counter offensive against the Borg Collective during their invasion that year. T'Prel, as well as Englehorn, Darrow, ch'Maras, and Malaya, were part of Lonnoc Kedair's strike team when the Aventine attacked and boarded a Borg scout, hoping to secure its vinculum. Englehorn and Darrow alternated fire with T'Prel and Kedair to battle waves of Borg drones, while ch'Maras and Malaya guarded the rear flank; T'Prel's shots were efficient, as each bullet in a fast series of single shots found its mark at a drone's throat, just above the sternum. After dispatching their attackers, ch'Maras and Malaya took point as they moved deeper into the craft. Kedair accidentally caused a friendly fire incident, resulting in several casualties and deaths, but T'Prel reminded her that they should keep moving; for her urgings, T'Prel was ordered to take point with Englehorn.