T'Pel was the Vulcan wife of Starfleet officer Tuvok – together they were the parents of three sons (one named Sek) and one daughter, Asil.
T'Pel married Tuvok in 2304.
Captain Kathryn Janeway (a friend of the family) spoke to T'Pel shortly before USS Voyager left on its mission in 2371, which included finding Tuvok. Janeway later told Tuvok about this once he was found. Janeway said that she and his family were "well, but worried about him." Tuvok corrected her that worry is an emotion, and she said that they "missed him." Tuvok admitted he missed his family as well.
When Starfleet learned that Voyager's crew was still alive and trapped in the Delta Quadrant after The Doctor had been transmitted to the Alpha Quadrant, the families of Voyager's crew were informed that they were still alive, including Tuvok's wife and family. T'Pel later wrote a letter to him, transmitted through a Hirogen communications network, telling him that he was a grandfather and that she asked the monks at the Temple of Amonak to say prayers for his safe return.
Having joined her husband aboard the USS Titan in 2380, T'Pel became the medical assistant to the ship's Chief Medical Officer, Dr. Shenti Yisec Eres Ree.