Lursa was the elder of the two Duras sisters who were responsible for the beginning of the Klingon Civil War in 2367. She was the mastermind behind her family's fight to head the Klingon Empire. With the assistance of the Romulans, Lursa and her sister B'Etor plotted to install Toral, the illegitimate son of Duras , on the throne of the Klingon High Council. She attempted to persuade Jean-Luc Picard , who was the Arbiter of Succession, to rule in favor of Toral. When Picard supported Gowron, she and her sister took up arms against Gowron. Their attempt was defeated when the Federation blockaded delivery of supplies from the Romulans . When the Romulan involvement was exposed, Lursa's support evaporated.
The Duras sisters were also responsible for selling bilitrium to Bajoran Kohn-Ma terrorists in 2369. This plot was revealed through investigation by Elim Garak and Julian Bashir . They did this in order to obtain capital to rebuild their forces.
Another capital-raising scheme had them seizing a Pakled magnesite mine on Kalla III, overseen by the Dopterian Gorta, and selling its explosive ore to a Yridian, Yog. In 2370, they were also falsely accused of plotting to kill Worf and his son. During that same year, her sister was pregnant with her first child.
In 2371, the sisters worked with El-Aurian scientist Tolian Soran and raided a Romulan outpost to acquire trilithium in exchange for Soran's trilithium weapon. Lursa died above Veridian III when her Bird-of-Prey was destroyed by the USS Enterprise-D.